C(RGDfK(N3)) hmoov yog dab tsi?

C(RGDfK(N3)) Powder(CAS: 868845-09-4) yog cyclic RGD peptide derivative uas muaj azide functional group rau bio-conjugation. Nws yog dav siv los ua kev tshawb fawb peptide hauv thaj chaw xws li kev xa tshuaj tshuaj, kev tshuaj ntsuam xyuas molecular, biomaterials, thiab kev tshawb fawb qog noj ntshav.

Cov peptide no belongs rau tsev neeg ntawm integrin- tsom ligands, tsim los tshwj xeeb khi rau v 3 integrin receptors, uas tau nthuav tawm heev hauv cov qog hlwb, cov hlab ntsha angiogenic, thiab qee cov ntaub so ntswg.

Cov ntaub ntawv tshuaj thiab cov qauv

Khoom npe	C(RGDfK(N3))
Cov lus piav qhia tag nrho	Cyclo(Arg-Gly-Asp-D-Ph-Lys(N₃)))
Peptide hom	Cyclic pentapeptide
Pab pawg ua haujlwm	Azide (–N₃)
Qhov tshwm sim	Dawb kom tawm -dawb lyophilized hmoov
Purity	Feem ntau Ntau dua lossis sib npaug li 95% (HPLC)
Solubility	Soluble hauv dej Soluble hauv DMSO thiab DMF
Cia	-20℃pom zoo

Cov ntsiab lus tseem ceeb

Cov peptide muaj:

RGD motif (Arg-Gly-Asp)

Lub luag haujlwm rau kev lees paub integrin

D-phenylalanine

Txhim kho metabolic stability

Cyclized qaum

Txhim kho receptor affinity thiab tsis kam mus rau enzymatic degradation

Azide- hloov kho lysine

Enables nyem chemistry conjugation

Khoom Specifications rau kev tshawb fawb siv

Raws li qib siab - cov tshuaj tshawb fawb muaj txiaj ntsig, nws cov lus qhia tshwj xeeb tau lees paub tus kheej, kev coj dawb huv, thiab kev ua haujlwm.

Parameter	Specification
Purity (HPLC)	Ntau dua lossis sib npaug li 95% (Standard), Ntau dua lossis sib npaug rau 98% (High-Purity)
Mass Spectrometry (MS)	ESI-MS lossis MALDI-TOF MS cov ntaub ntawv lees paub qhov tseeb molecular mass (Dawb puag: ~ 678.8 Da; Daim ntawv ntsev: + pawg ntawm counterions).
Cov ntsiab lus Peptide	Muab cov ntsiab lus peptide net (piv txwv li, "Net Nyhav: 1 mg peptide").
Amino Acid Analysis (AAA)	Kev sib xyaw ua ke sib piv theoretical.
Sterility & Endotoxin	Tsis muaj menyuam, Endotoxin: <1.0 EU/mg (rauhauv vitrosiv). Rauhauv vivodaim ntawv thov, tshwj xeeb qis -endotoxin synthesis yog xav tau.
Cia & Reconstitution	Khaws ntawm tsawg dua lossis sib npaug rau -20 degree, qhuav.Rov ua dua nyob rau hauv siab -zoo, azide-dawb buffers (xws li, PBS, saline) los yog dej tsis muaj menyuam. Zam kom tsis txhob muaj amine- muaj cov buffers (piv txwv li, Tris) thaum lub sij hawm conjugation vim lawv tuaj yeem hnov qab.

Kev Tshawb Fawb Kev Tshawb Fawb & Ua Ntej -Cov Ntawv Thov Kev Kho Mob

Qhov no dual{0}}functionality ua rau nws siv raws li ib tug universal platform rau tsim cov hom phiaj theranostic agents.

Daim ntawv thov teb	Tshwj xeeb peb
Molecular Imaging	Tumor{0}}Targeted PET/SPECT/Fluorescent Imaging Probes
Targeted Drug Delivery	Ligand rau Active Targeting ntawm Nanocarriers.
Tshuaj Biology	Kev soj ntsuam rau Integrin Biology & Cell Surface Labeling.
Theranostics	Combined Diagnostic & Therapeutic Agents.

Core Functional Properties: Dual -Action Molecule

Cov molecule no muaj ob qhov sib txawv, tsis tau ntxiv, txheej ntawm kev ua haujlwm:
Txheej 1: Lub Hom Phiaj Xwm Txheej (Lub "Warhead")

Lub Hom Phiaj: v 3 Integrin Receptor. Cov receptor no tau nthuav tawm ntau dhau ntawm cov kab mob endothelial ntawm cov qog neovasculature thiab ntawm ntau cov qog nqaij hlav qog nqaij hlav (xws li, glioblastoma, melanoma, mis, mob qog nqaij hlav prostate), tab sis feem ntau tsis tuaj ntawm cov hlab ntsha, cov hlab ntsha thiab cov nqaij mos feem ntau.
Mechanism: Cyclic RGD motif ua raws li qhov siab -affinity, tshwj xeeb ligand rau v 3. Nws txoj hlua khi tuaj yeem cuam tshuam kev sib cuam tshuam ntawm cov integrin thiab extracellular matrix proteins (xws li vitronectin thiab fibronectin), cuam tshuam pro- ciaj sia taus thiab pro{{3}angiogenic.

Txheej 2: Tshuaj Conjugation (Lub "Handle")
Reactive Group: Azide (-N₃) yog ib pawg me me, ruaj khov, thiab bioorthogonal ua haujlwm.
Conjugation Chemistry: Nws nkag siab koom nrog Click Chemistry cov tshuaj tiv thaiv, feem ntau:

Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC): Nrog lub davhlau ya nyob twg alkynes, catalyzed los ntawm Cu(I).
Hom -Promoted Azide-Alkyne Cycloaddition (SPAAC): Nrog strained cyclooctynes (xws li, DBCO, BCN) - qhov tseem ceeb, cov tshuaj tiv thaiv no yuav tsum tsis muaj cytotoxic tooj liab catalyst, ua rau nws zoo tagnrho rau hauv vitro thiab vivo daim ntaub ntawv.

Kev siv hluav taws xob:Qhov no tso cai rau covalent, qhov chaw - tshwj xeeb, thiab siab - ua haujlwm tau zoo ntawm txhua yam molecule uas muaj "nyem" tus khub (alkyne/cyclooctyne).

C(RGDfK(N3)) Powder(CAS: 868845-09-}4) yog ib tug high-affinity cyclic RGD peptide nrog azide functional pab pawg, ua rau nws yog ib tug haib cuab tam rau integrin-targeted imaging, xa tshuaj, thiab biomaterials tshawb fawb. Nws txoj kev ruaj ntseg, tshwj xeeb rau v 3 integrin, thiab kev sib raug zoo nrog nias chemistry ua rau nws muaj txiaj ntsig zoo hauv kev tshawb fawb biomedical thiab tshuaj niaj hnub.

Cim npe nrov: c(rgdfk(n3)) hmoov cas 868845-09-4, Tuam Tshoj c(rgdfk(n3)) hmoov cas 868845-09-4 manufacturers, lwm tus neeg, Hoobkas