Carboplatin Powder yog dab tsi?
Carboplatin Powder (CAS Tsis yog. 41575-94-4) yog platinum-raws li cov khoom sib xyaw ua ke nyob rau hauv pawg antineoplastic API. Nws yog muab los ua ib qho tshuaj active ingredient los yog kev tshawb fawb -qib cov ntaub ntawv rau siv nyob rau hauv formulation txoj kev loj hlob.
Raws li qhov thib ob - tiam platinum derivative, carboplatin tau ua tus cwj pwm hauv cov ntaub ntawv luam tawm los ntawm nws cov ntaub ntawv tshuaj tshuaj txheeb ze rau cov neeg ua haujlwm platinum ua ntej. Nws txoj kev loj hlob tau raug ceeb toom los ntawm kev siv zog los tshawb nrhiav lwm txoj kev nyab xeeb thiab cov yam ntxwv ntawm kev zam, nrog cov ntaub ntawv sib txawv ntawm lub raum thiab plab hnyuv cuam tshuam piv rau lwm yam platinum-raws li cov khoom sib xyaw.
Rau kev tsim kho, kev tswj xyuas, lossis daim ntawv thov kev tshawb fawb, thov sab laj nrog koj cov pab pawg sab hauv thiab kev tswj hwm kom ua raws li cov kev cai hauv cheeb tsam.
Chemical & Physical Yam ntxwv
- Lub npe tshuaj: Carboplatin
- IUPAC lub npe: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
- Cov mis mos molecular: C₆H₁₂N₂O₄Pt
- Molecular Luj: 371.25 g / mol
- CAS Nr .: 41575-94-4
- Cov tsos mob: Dawb rau tawm -dawb crystalline hmoov
- Solubility: me ntsis soluble hauv dej
- pH (kev daws): Feem ntau nruab nrab rau me ntsis acidic
- Stability: rhiab heev rau lub teeb thiab muaj zog oxidizing / txo cov neeg ua haujlwm
Carboplatin muaj lub chaw platinum hlau, uas yog lub luag haujlwm rau nws cov haujlwm tiv thaiv kabmob.
Khoom Specifications
Raws li kev txhaj tshuaj tiv thaiv kab mob API, cov lus qhia tshwj xeeb tshwj xeeb, tsom rau purity, impurity profiling, thiab kev ruaj ntseg tsis muaj menyuam.
|
Parameter |
Specification |
|
Kev ntsuam xyuas (HPLC) |
98.0% - 102.0% (ntawm anhydrous, hnyav-dawb hauv paus) |
|
Cov khoom tsis huv (HPLC) |
Ib tus neeg paub txog impurities: Kev txwv nruj rau Cisplatin (genotoxic), Transplatin, Carboplatin dimer, CBDCA-txog impurities. Tag nrho impurities: Tsawg dua lossis sib npaug li 2.0%. |
|
Platinum Cov ntsiab lus (AAS) |
51.0% - 53.5% ntawm txoj kev xav (~ 52.3%) |
|
Cov kab mob endotoxins |
< 1.0 EU/mg (or per vial spec for final product) |
|
Tsis muaj menyuam |
Yuav tsum ua raws li kev xeem tsis muaj menyuam (rau API npaj rau kev ua kom tsis muaj menyuam). |
|
Cov ntsiab lus dej (KF) |
Tsawg dua lossis sib npaug li 0.5% |
|
Cia & Txee Lub neej |
24-36 lub hlis nyob rau hauv thawj ntim ntim, tiv thaiv los ntawm lub teeb thiab noo noo ntawm chav tsev kub tswj. |
Mechanism ntawm Action & Pharmacology
Carboplatin Powder (CAS No. 41575-94-4) yog lub voj voog ntawm tes uas tsis yog - tus neeg sawv cev tshwj xeeb alkylating. Nws cov txheej txheem tseem ceeb suav nrog kev tsim cov cytotoxic platinum-DNA adducts.
Qhib qhib:Hauv qhov qis -chloride intracellular ib puag ncig, lub labile cyclobutanedicarboxylate (CBDCA) ligand tau hloov los ntawm cov dej molecules, tsim cov reactive aquaated hom.
DNA Binding:Cov activated platinum complexes covalently khi rau purine bases (feem ntau N7 ntawm guanine thiab adenine) nyob rau hauv DNA, tsim intrastrand thiab interstrand cross-links. Qhov no cuam tshuam DNA qauv thiab kev ua haujlwm, inhibiting replication thiab transcription.
Qhov tshwm sim ntawm Cellular:Qhov kev puas tsuaj DNA ua rau txoj hauv kev nyuaj ntawm cov xov tooj ntawm tes, thaum kawg ua rau apoptosis (programmed cell tuag) hauv cov cell faib sai, xws li cov qog nqaij hlav cancer.
Ntsiab Pharmacokinetic Feature:Tsis zoo li cisplatin, carboplatin qhov reactivity qis dua, thiab nws qhov kev tshem tawm feem ntau yog lub raum, zoo sib xws nrog glomerular filtration rate (GFR). Qhov no tso cai rau kev txhaj tshuaj meej meej siv Calvert mis (Dose=Lub Hom Phiaj AUC x [GFR + 25]), txo qis toxicity.
Vim li cas thiaj xaiv TNJONE Carboplatin Powder?
TNJONECarboplatin hmoov(CAS Tsis yog. 41575-94-4) yog qib siab -purity, tshuaj- cov khoom xyaw nquag siv dav hauv kev tshawb fawb thiab kev siv tshuaj. Ua raws li cov qauv GMP nruj, txhua pawg muab cov khoom zoo sib xws nrog cov ntaub ntawv dav dav, suav nrog COA, cov ntaub ntawv ruaj khov, thiab cov ntaub ntawv txhawb nqa. Kev ntseeg siab los ntawm cov kws tshawb fawb thiab cov kws tsim tshuaj rau kev txhim kho kev ua tau zoo thiab cov khoom sib xws, peb muab cov khoom siv tau yooj yim los ntawm R & D kom muaj nuj nqis rau kev lag luam ntim, txhawb nqa los ntawm kev txhawb nqa kev txhawb nqa thiab kev txhawb nqa thoob ntiaj teb. Tiv tauj peb hnub no los thov cov lus qhia lossis cov qauv.
TNJONECov khoom yog tsim los rau kev tshawb fawb thiab kev lag luam siv nkaus xwb. Tsis yog npaj rau kev kho mob lossis kev kho mob.
Cim npe nrov: Carboplatin hmoov cas 41575-94-4, Tuam Tshoj carboplatin hmoov cas 41575-94-4 manufacturers, lwm tus neeg, Hoobkas
